Royal Society Summer Science Exhibition

Every summer, the Royal Society in London opens their doors to the public for the Summer Science Exhibition – a week-long science fair, where universities and research institutes from across the UK show off some of their coolest and most popular research. The University of Leicester was there with a replica of the skeleton of King Richard III, whom they found buried under a parking lot a few years ago. The National Physical Laboratory and University of Coventry brought some conductive fabrics. The Royal Geographical Society had a block of ice and 3D images to illustrate their work studying glaciers at Mount Everest. And all of this in the beautiful Royal Society building, with paintings of former presidents (Newton!) on the walls and old equipment showcased in the hallways.

There were some talks and events throughout the week as well, but I didn’t make it to the exhibition until Sunday, and only had time to walk past the stands.

Here’s a quick impression of some of the things I saw!


Filed under: Have Science Will Travel Tagged: Royal Society, Summer Science Exhibition

Mitochondrial Royalty

front-matterOur own Michele Banks provided the cover art for a mitochondria themed issue of Philosophical Transactions of the Royal Society B (B is for Biological Sciences). The Royal Society traces its roots back to 1660. Philosophical Transactions dates back to 1665 and the splitting into and dates to 1887

We could not be prouder of Michele for contributing to the merger of art with this long scientific tradition, nor could we be prouder of the Royal Society for showing excellent taste.


Filed under: The Art of Science Tagged: Artologica, cover art, Michele Banks, mitochondria, Royal Society, The Philosophical Transactions of the Royal Society B

Sir Henry Dale Fellowship

I am pleased to report that I have been awarded a Wellcome Trust and Royal Society funded Sir Henry Dale Fellowship. The subject of the fellowship, to be held in the Nuffield Department of Medicine at the University of Oxford, is Statistical Methods for Whole Genome Phenotype Mapping in Bacterial Populations.

The project addresses the question of how to detect genes or mutations in bacteria responsible for variability in important traits such as the tendency to cause human disease. Focusing on the hospital-associated pathogens Staphylococcus aureus and Clostridium difficile, the project has the potential to help identify genetic variants that explain why some bacteria cause more severe infections, knowledge that could help develop new drugs and tests that improve patient treatment.

The fellowship runs for five years, and includes support for a postdoctoral research assistant and laboratory costs. I will be advertising a position shortly. If you are interested, please get in touch.

I want to thank the funders and reviewers for supporting this project, and my colleagues who helped me write and re-write the research proposal.

Coalescent inference for infectious disease

Today my student Bethany Dearlove has her first paper published, called Coalescent inference for infectious disease: meta-analysis of hepatitis C. In this paper, published in Philosophical Transactions of the Royal Society B, we have developed coalescent-based population genetics methods for popular, deterministic, epidemiological models known as SI (susceptible-infectious), SIS (susceptible-infectious-susceptible) and SIR (susceptible-infectious-recovered). By implementing these methods in BEAST, we were able to re-analyse previously published hepatitis C virus datasets and directly estimate epidemiological parameters. Our results show that, in the absence of co-infection, the widely-used exponential growth and logistic growth models of changing population size correspond directly to SI and SIS dynamics. We were also able to examine the limitations to genetic approaches to reconstructing epidemiological dynamics.

This paper appears as part of an issue on Next-generation molecular and evolutionary epidemiology of infectious disease, which accompanies a Royal Society discussion meeting organized by Oli Pybus, Christophe Fraser and Andrew Rambaut. The Royal Society has made audio recordings of the talks at this meeting, and the accompanying satellite meeting, available online, including my talk on Bethany's paper.