New Lab Matters: Sharing the value of public health laboratories

New Lab Matters: Sharing the value of public health laboratories | www.APHLblog.org

The need for a laboratory voice in budgetary discussions has become more urgent recently, and “human-to-human relationships” are as critical as technical knowledge. So how does a public health laboratory raise its profile within the community? By telling a good story…over and over again.

In the summer issue of Lab Matters, our feature article examines how laboratories are sharing their value, one interview, photo or outreach moment at a time.

Here are just a few of this issue’s highlights:

Subscribe and get Lab Matters delivered to your inbox, or read Lab Matters on your mobile device.

The post New Lab Matters: Sharing the value of public health laboratories appeared first on APHL Lab Blog.

Farewell, Providence! APHL Annual Meeting — Days 3 and 4

Farewell, Providence! APHL Annual Meeting — Days 3 and 4 | www.APHLblog.org

After four days of fascinating speakers, networking with peers and partners from around the world, and enjoying public health jokes that only insiders would understand, the 2017 APHL Annual Meeting came to a close. It was the largest meeting yet with over 700 attendees. We are so thankful to the APHL staff, members, partners, exhibitors and speakers who made this meeting a success! See you all in Pasadena, California in 2018!

Below is a round-up of days 3 and 4.

Day 1 round-up

Day 2 round-up

The post Farewell, Providence! APHL Annual Meeting — Days 3 and 4 appeared first on APHL Lab Blog.

APHL Annual Meeting — Day 2

APHL Annual Meeting — Day 2 | www.APHLblog.org

It was another great day at the APHL Annual Meeting! From cholera to opioids to storytelling, the day was packed full of fascinating presentations from experts. Follow #APHL on Twitter and Instagram to join the conversation!

Day 1 round-up

The post APHL Annual Meeting — Day 2 appeared first on APHL Lab Blog.

UberOps CEO talks public health in the cloud

UberOps CEO talks public health in the cloud | www.APHLblog.org

In a very short time, Americans have become increasingly familiar with the cloud. Not the white fluffy ones in the sky, but the cloud where much of our day-to-day computing takes place. Even for people who aren’t familiar with the term, they likely are familiar with the concept of accessing internet-based files from anywhere. Photos taken on your smartphone might be automatically uploaded to a cloud-based storage system where you can view or download those photos on your laptop. Just as this technology has become valuable in our daily lives, it has become valuable in public health.

At this year’s APHL Annual Meeting, Eduardo Gonzalez Loumiet, CEO of UberOps, presented on public health in the cloud. We asked Eddie a few questions about the system that he has worked to develop along with APHL informatics and the value that this platform offers public health laboratories and ultimately the American public.

Learn more about AIMS — AIMS Platform: Outpacing Pathogens from the Cloud

In simple terms, what is the AIMS platform? What is the role of UberOps?

AIMS stands for the APHL Informatics Messaging Services Platform. AIMS was developed in 2008 as part of the Public Health Laboratory Interoperability Project (PHLIP) focused on influenza surveillance with the CDC.

AIMS is a secure, cloud based environment that accelerates the implementation of health messaging by providing shared services to aid in the transport, validation, translation and routing of electronic data.

The AIMS Platform has grown to a community of more than 85 trading partners involved in several use cases including ELR, Whole Genome Sequencing, ARLN and NMI. New use cases are being discovered every day.

UberOps is an APHL partner that develops and supports the AIMS Platform. We work on the deep technical aspects of AIMS. Our focus is on continuously securing the environment, trading partner onboarding, and ensuring trading partners have the information and tools to leverage AIMS Platform benefits.

Why should public health labs use a cloud-based system? What are the benefits? 

The benefits of using cloud computing have surpassed perceived risks. AIMS utilizes Amazon Web Services (AWS), the industry leader in Cloud computing. The benefits of cloud computing include:

  1. Security, high availability and reliability
  2. Centralized processing and message routing
  3. Real-time monitoring and audit systems
  4. Reduced message transport complexity
  5. Reduced data translation and transformation complexity
  6. Reduced development and support costs
  7. Flexible capacity infrastructure
  8. FISMA Moderate compliant applications
  9. FedRAMP compliant environment via the cloud provider
  10. Commitment to innovation and the future

Are public health laboratories the only labs using AIMS?

UberOps CEO talks public health in the cloud | www.APHLblog.org

AIMS was built to serve public health laboratories. Over the last 18-24 months the AIMS infrastructure has expanded capability to allow public health agencies and a select group of private laboratories to securely exchange data as well. We have also seen an increase in cross-jurisdictional ELR data exchange between agencies. AIMS has also been used to host other non-profit data, such as STEVE 2.0, which focuses on exchanging birth and death records between states. And AIMS is being used to process data for the first time in the cloud through virtual workstations for the whole genome sequencing project. We are excited for the emerging possibilities!

Is it secure? How do I know my information wont be stolen or misused?

The top priority for APHL and UberOps is a secure and compliant AIMS Platform. Stringent healthcare laws and regulations across jurisdictions are monitored on a regular basis, and revisited on a regular basis. The AIMS Platform is FISMA Moderate compliant, which requires a once per year third-party audit. In addition to the audit, the AIMS infrastructure is required to pass firewall penetration testing.

Each member of the AIMS Platform team attends yearly HIPAA privacy and security training. The AIMS dedicated security team uses advanced, real-time monitoring tools to proactively eliminate potential threats.

What does this mean for the public? Are there clear benefits for people in the community?

AIMS is an extension of everything our public labs represent in the United States. The ability to monitor and detect health threats quickly using a shared technology platform is an invaluable asset for the safety of all citizens. Preventing and/or predicting large expected (like influenza) and unexpected (like Zika) public health events is where the AIMS Platform serves our communities.

What does the future hold for AIMS?

APHL, UberOps and AIMS stakeholders are constantly looking to expand the functionality of the AIMS infrastructure. As the evolution of health data continues, we see new opportunities to assist with integrating data and providing a higher quality experience for trading partners, patients and citizens.

Our recent platform growth between public and private collaboration will continue, and we expect to expand AIMS application services (examples: Dashboards, Portals, LIMS), electronic case reporting and much more!

 

The post UberOps CEO talks public health in the cloud appeared first on APHL Lab Blog.

AIMS Platform: Outpacing Pathogens from the Cloud

AIMS Platform: Outpacing Pathogens from the Cloud | www.APHLblog.org

By Rachel Shepherd, associate specialist, Informatics, APHL

​​In a kindergarten classroom in Des Moines, a small boy begins to shiver uncontrollably. In a nursing home in Phoenix, a pneumonic grandmother fights for her life from a hospital bed. On a crowded metro car in Washington, DC, in the miniscule droplets of saliva from a man’s kind “Hello” to a stranger, it attacks. The flu. It comes every year as the months begin to shift into winter, returning slightly different than before, exploding and thriving, determined to wreak havoc. It descends upon the nation, preys upon us in our most vulnerable moments, and says, “This is my  year.”

In public health, every emerging threat—the flu, E. coli, Legionnaires’ disease, Ebola, Zika—is a race against time. What can scientists learn from these deadly pathogens, and more importantly, how fast? Lives depend on this data, on laboratories’ ability to track patterns, decipher mutations and to share, compare and build upon those findings—crowdsourcing at its finest and most critical.

Only a few years ago, a lab would manually enter its test results and fax them to CDC and other reference centers. Someone would receive the paper transmission and manually re-enter it. The process would take days. In that time, an outbreak could have spread. Lives could have been lost.

Time matters. But thanks to an APHL-CDC initiative, what used to take days can now take minutes. In 2008, public health labs recognized the need to share their data electronically. APHL worked hand in hand with informatics specialists at state labs and CDC to develop what was then known as the Route not Read (RnR) hub. This seemingly simple, but powerful approach sent public health data through a service that read the outside envelope of the electronic message and delivered it to the intended recipient without opening its contents.

Four years later, the increasing complexity and demands for public health data led to the development of the AIMS platform. Now in a cloud-based environment, AIMS has burgeoned over the years. The new environment accelerates the transmission of data and provides shared services, such as message validation translation, to labs and trading partners. Today, more than 85 organizations and institutions exchange data over AIMS, with more than 25 million messages transported to date.

The vital data exchanged on AIMS includes aggregated influenza test results from public health laboratories to CDC, vaccine-preventable disease reports, biological threat data, immunization data exchange among several public health jurisdictions, electronic laboratory reporting between hospitals and their jurisdictions, and whole genome sequencing through the Advanced Molecular Detection initiative. And AIMS is expanding again to offer electronic case reporting to connect laboratories and health agencies with CDC and with other data recipients nationwide.

Since its launch in 2012, the AIMS platform has equipped public health officials to monitor and respond rapidly to health threats, strengthened labs with shared resources and expedited delivery of time-sensitive health information to consumers. As the platform continues to gain traction, its contributions to the nation’s health infrastructure will be tremendous.

The post AIMS Platform: Outpacing Pathogens from the Cloud appeared first on APHL Lab Blog.

New Lab Matters: Cannabis testing and public health laboratories

New Lab Matters: Cannabis testing and public health laboratories | www.APHLblog.org

As it stands today, cannabis is a Schedule I narcotic, on the same US government list as heroin, ecstasy and other illicit drugs deemed to have high abuse potential. For 28 states and the District of Columbia where cannabis is legal for medical and/or recreational adult use, this is a huge problem, especially for state agencies and laboratories tasked with regulatory oversight and public health surveillance of cannabis safety.

In the spring issue of Lab Matters, our feature article examines how public health laboratories are responding to this unique challenge.

Here are just a few of this issue’s highlights:

Subscribe and get Lab Matters delivered to your inbox, or read Lab Matters on your mobile device.

The post New Lab Matters: Cannabis testing and public health laboratories appeared first on APHL Lab Blog.

APHL and EPA formalize environmental health partnership

APHL and EPA formalize environmental health partnership | www.APHLblog.org

By Scott J. Becker, executive director, APHL

Earlier this week, on behalf of APHL, I had the honor of signing an agreement with the Environmental Protection Agency (EPA) formalizing what will be an invaluable partnership. Leading our nation in environmental science, research and innovation, the EPA’s commitment to health is as strong as ours. Coupled with APHL’s work to promote environmental and public health laboratory science, together we can better understand public health risks and respond to them efficiently and effectively. We have worked closely with EPA in the past through the Water Laboratory Alliance, National Biomonitoring Network Steering Committee and many other efforts, and look forward to this formal relationship and increased opportunity for collaboration.

APHL and EPA formalize environmental health partnership | www.APHLblog.orgSigning this new memorandum of understanding (MOU) was not only an exciting statement of cooperation, but also a great opportunity to discuss goals with my friend, Dr. Tom Burke, deputy assistant administrator of EPA’s Office of Research and Development (ORD). Dr. Burke wrote a great blog post about our new partnership. And you can see a brief video of us discussing the importance of this collaboration. I am so appreciative of his commitment to protect the public’s health and to our partnership.

Special thanks to some key people who began the dialogue with EPA years ago, and others who pushed this forward in recent times:  Dr. Jim Pearson, former director of Virginia’s Division of Consolidated Laboratory Services and past APHL president; Ramona Travato, formerly in many roles at EPA; Kacee Deener, senior science advisor, EPA ORD; Dr. Megan Latshaw, formerly APHL’s director of environmental health and currently co-director of the Master of Health Science in Environmental Health Program at Johns Hopkins University; Julianne Nassif, APHL’s director environmental health program; and Sarah Wright, APHL’s senior specialist for environmental laboratories.

This was a team effort from the beginning and will continue as such into the future. Now it’s time to get to work!

The post APHL and EPA formalize environmental health partnership appeared first on APHL Lab Blog.

When and why is it legal to not follow the DOT packaging instructions? 

When and why is it legal to not follow the DOT packaging instructions? | www.APHLblog.org

By Patricia Payne, president, JBM Associates, Inc.; consultant, APHL

If you have completed any packaging and shipping training, you are undoubtedly aware that you must always follow the packaging instructions as written in the hazardous materials transportation regulations. However, sometimes it may be as safe, less costly or more efficient to do it another way. In some instances, it may be impossible to follow the current regulations.

If you have ever encountered any of those situations, a legal alternative is available in the form of a special permit. A special permit is a document that permits a person to perform a function that is not otherwise allowed under the Hazardous Materials Regulations (HMR). A special permit sets forth alternative requirements, or variances, to the requirements of the HMR. The Pipeline and Hazardous Materials Safety Administration (PHMSA) is authorized to issue such variances if the proposed method achieves a safety level that is at least equal to that required under federal hazmat law or is in the public interest if a required safety level does not exist.

In the past, special permits have been issued to clinical and research laboratories and medical facilities for a variety of reasons. Two of the reasons were:

  1. To allow transport of a Category A infectious substance in non-Class 6.2 packaging, and
  2. To conduct exercises with mock specimens to test preparedness for chemical exposure due to a terrorist event.

Clinical and research labs maintain stocks of infectious substances for a variety of reasons, including quality control, method validation and training purposes. Permits have been requested and issued for the motor vehicle transport of stocks of Biological Substances Category B from one location to another in the freezers in which they were stored instead of packaging separately, according to the HMR. This saved both time and money in transporting those cultures to a new facility.

When the first patients with Ebola were being treated in the US, it became apparent that packaging did not exist to hold the quantities of Category A infectious substances being generated from the biological waste produced by patient treatment. The biological waste generated from treatment of patients with most infectious agents is classified as Regulated Medical Waste. However, the waste generated from an Ebola patient is classified as an Infectious Substance Affecting Humans and must be packed in Class 6.2 UN specification packaging. Because packaging did not exist to hold the quantities being generated, a special permit was issued to package that waste in a manner not otherwise allowed by the HMR.

For preparedness purposes, public health agencies often develop exercises or drills to prepare for shipping infectious agents in the event of a public health threat or outbreak. Because the drills evaluate the participants’ ability to correctly package an infectious agent being sent to a reference lab without delay but are not evaluating the actual testing of those agents, infectious agents are not required to be placed in the package during these exercises. However, the HMR prohibits offering a package marked as containing hazardous materials if it does not contain a known or suspected hazardous material. In the past, special permits have been issued to allow chemical terrorism exercises to test preparedness for shipping samples for Rapid Toxic Screens using mock Category B infectious substances. Currently, a special permit request is in preparation for drills testing preparedness for correctly packaging a Category A infectious substance, such as Ebola. For obvious reasons, the permit will request that mock non-infectious agents be substituted for the purposes of the drill.

It is important to note that special permits must be requested in writing at least 120 days in advance and that you must wait for approval before packaging in a non-compliant manner. Permits are generally issued for the use of one agency. However, other agencies can request to use the same permit and be granted party status to use it.

The PHMSA website provides information on the process for requesting a special permit, a searchable database of previously issued permits and contact information for support.

Learn more about APHL trainings.

 

This post wasn’t written by an APHL staff member and the views expressed in the post are those of the guest author and do not necessarily reflect the views or opinions of APHL. If the post contains an evaluation or opinion about a product or service, this represents the guest blogger’s personal belief and does not represent APHL’s endorsement or critique.

 

Inside the public health lab Zika response: ‘It’s the great unknown as to how much longer this will go on’

Inside the public health lab Zika response | www.APHLblog.org

By Kim Krisberg

Public health laboratory scientists are well used to the preparations and demands that come with emerging disease threats. But Zika virus is different.

“With SARS, West Nile virus, H1N1 flu, mumps outbreaks — those came and were gone in a few months,” said Michael Pentella, PhD, director of the state public health laboratory at the Massachusetts Department of Public Health. “We’ve been ramping up and dealing with Zika for a long period of time now and there’s no end in sight.”

While the Aedes aegypti mosquito — the species by which Zika is most commonly spread — is not found in Massachusetts, the state’s public health lab began preparing for the disease in late 2015. At first, the pace of testing was fairly slow, Pentella said, with the lab receiving less than 20 specimens a week as of January. The weekly volume quickly ramped up to about 150 a week in February, then slowed around the time that officials began warning at-risk populations to avoid travel to high-transmission regions. As of early September, volume was back up, with about 130 specimens arriving at the Massachusetts state lab every week. Most of those specimens are coming from Massachusetts residents, but the lab is also providing testing for a handful of other states where Zika testing is not yet fully operational.

At the moment, Pentella said Zika testing is “by no means overwhelming” the lab’s capacity, though he said it is adding significantly to staff workload. He is worried, however, that if another health threat arises on top of Zika, it could quickly push the lab to capacity. For example, the same personnel who conduct Zika testing also perform influenza testing. So if the upcoming flu season is particularly bad or a new flu strain emerges as Zika demands continue inching upward, “I’m very worried about our ability to handle both at the same time,” Pentella said.

Public health systems, including labs, continually prepare and practice for the possibility of outbreaks and disasters, and staff are ready for the additional duties that come with understanding, monitoring and containing a dangerous pathogen. Still, effective and sustained response requires sufficient funding. And in the case of Zika — a complicated disease with multiple modes of transmission and the potential for devastating birth defects — that funding has hardly been forthcoming. As of Sept. 20, with more than 20,000 Zika cases confirmed in U.S. states and territories, including 43 locally acquired cases in U.S. states, Congress had yet to authorize emergency funding for Zika response.

The White House first submitted its request for $1.9 billion in emergency Zika funds back in February based on recommendations from the scientific and public health community. But instead of acting quickly on those recommendations, Congress deadlocked on the issue. To make matters worse, that inaction comes on top of years of declining public health preparedness funding at the federal level as well as declining state and local public health budgets. Inside a public health lab, that funding inaction can have an acute effect. The equipment and its maintenance are expensive, the training is complex and the skill set is competitive. Yet, public health labs are indispensable to combating a disease like Zika. They provide the data that shape and drive effective interventions and provide testing services for all residents, regardless of their ability to pay.

And even though the U.S. is well into mosquito season, public health officials like Pentella say federal emergency funding is still needed — urgently.

“We need to take the broader perspective and look longer term so we’re not constantly on this yo-yo of ramping up and ramping down because funding goes away,” he said. “[Federal Zika funding] is becoming more urgent every day. I see the possibility of us falling behind and it will limit our capacity to respond. It really is tying our hands when we need to have all hands on deck.”

Zika lab response: ‘We’re in a very tenuous place’

Today, thankfully, there is nationwide coverage for the three tests used to screen for Zika virus, with public health labs bearing the majority of the testing burden but some commercial and clinical labs receiving authorization from the Centers for Disease Control and Prevention (CDC) to test as well. What’s unique about Zika, however, is that it requires both molecular and serological diagnostics.

Inside the public health lab Zika response | www.APHLblog.orgOn the molecular side, nearly every public health lab in the country has been confirmed to screen for Zika via polymerase chain reaction (PCR) testing, which CDC recommends for symptomatic patients tested less than 14 days after the initial onset of symptoms as well as for asymptomatic pregnant women who may have been exposed to the mosquito-borne virus. A positive PCR requires no follow-up. If the result is negative, however, the next step is serological testing using the IgM Antibody Capture Enzyme-Linked Immunosorbent Assay (MAC-ELISA), which detects the antibodies the body uses to fend off Zika infection.

In addition to confirming a negative PCR result, the serological test is recommended for asymptomatic pregnant women tested 14 or more days after potential virus exposure as well as for symptomatic patients beyond the 14-day window from initial onset. The challenge is that the MAC-ELISA is incredibly complicated, the throughput takes days longer than PCR, and, in general, serological testing isn’t a typical component of a lab’s surge response.

Plus, many public health labs have either cut back or stopped ELISA testing altogether because of previous funding cuts, said Chris Mangal, director of public health preparedness and response at APHL. Those funding cuts meant many labs have had to spend valuable time and resources bringing their serological capacity back to the frontline. As of late summer, 43 public health labs could test for Zika using the MAC-ELISA.

“When Congress opts to not provide resources for these emerging threats, it has a big effect,” Mangal said. “Yes, they’re prepared by virtue of their membership in the [CDC Laboratory Response Network (LRN)], but you still have to keep replacing the gas in the gas tank, if you will. That one tank of gas won’t get you across the country.”

The MAC-ELISA may be the best way to identify Zika in asymptomatic patients, but it’s also incredibly nonspecific, said Kelly Wroblewski, director of infectious diseases at APHL. In other words, the ELISA can also pick up antibodies to dengue and West Nile virus, which are in the same genus of viruses as Zika, and that means a positive ELISA for Zika has to be confirmed with yet another highly complex test — the plaque reduction neutralization test (PRNT) — that only a small number of public health labs and CDC have the capacity to perform.

Fortunately, Wroblewski said, most labs are currently able to handle the volume of specimens coming their way, with the exception of Florida, which is being bombarded with testing demands in the wake of local mosquito transmission.

As of September 20, the Florida Department of Health reported nearly 700 travel-related Zika cases and 89 non-travel-related cases, 87 of which involved pregnant women. It also reported that the department had conducted Zika testing for more than 7,815 people so far, noting that it only has the capacity to test 4,930 people for active Zika (PCR) and 8,364 for Zika antibodies (ELISA). Florida is home to both mosquito species that carry Zika and mosquito season in the Sunshine State is pretty much year-round.

“I think we’re in a very tenuous place,” Wroblewski said. “This isn’t going to be something that goes away after mosquito season is over. The public health system has done an amazing job responding without congressional support…but once the immediate danger is over, we’re very likely going to be in the same position rolling into next mosquito season.”

Labs in action: High-risk to Big Apple

Texas is considered a high-risk state for Zika, as it shares a border with Mexico and is home to both mosquito species that transmit the virus. As of September 20, Texas had 195 reported cases of Zika, all travel-related or transmitted via sexual contact.

At the state public health lab in the capital of Austin, Grace Kubin, PhD, director of the Laboratory Services Section at the Texas Department of State Health Services, said the volume of Zika-related specimens arriving at the Austin lab every day has doubled since February — as of early September, the volume was about 50 a day. However, that number would be a good bit larger if Texas wasn’t able to spread its Zika testing demands across its network of state and local public health labs. Kubin said almost all LRN public health labs in Texas can perform the more rapid PCR test, while Austin- and Dallas-based public health labs can perform serological testing, with labs in Houston and San Antonio working to bring serological capacity online as well.

“I’m happy to report that of the specimens coming in, we seem to be keeping up,” Kubin said. “We don’t have a backlog for either PCR or serology. We’ve gotten to a comfortable place right now, where we’re able to test whatever comes our way.”

Bringing testing capacity online had its challenges, Kubin reported. While the PCR process was fairly typical, the serological response, i.e. MAC-ELISA, was much more difficult. The MAC-ELISA, which received emergency use authorization in February, came with very specific biosafety guidelines that apply to serious or potentially lethal agents and complying with those guidelines is no easy task, Kubin said. Another challenge for labs is simply the time it takes to run a MAC-ELISA. For example, for the PCR test, the Austin lab can process a plate of 38 specimens in just a few hours. Serology also runs on a plate, but it holds just eight specimens and takes three days to process. To speed things up, the Austin lab set up a new system that allows it to process multiple serology plates each day.

“We have a little bit of extra room that maybe other labs don’t have,” Kubin said, noting that the Austin-based lab is one of the largest public health labs in the country. “Being such a large lab with a lot of testing divided out as far as molecular techniques being done in different areas…it allows us the ability to ask for additional help.”

Of course, once a local mosquito-transmitted Zika case is detected in Texas, testing demands will likely surge — a turn of events the Austin lab is preparing for at the same time it responds to daily Zika needs. Kubin said the Iowa state public health lab has already offered its assistance to Texas in case Zika demands begin to overwhelm the Lone Star state.

“Zika will continue to be the next new thing,” she said.

Inside the public health lab Zika response | www.APHLblog.orgThe Aedes aegypti mosquito doesn’t travel as far north as New York City, but its relative and potential Zika vector, the Aedes albopictus, does. According to the New York City Department of Health and Mental Hygiene as of Sept. 9, the city was home to 568 Zika cases, all travel-associated. Scott Hughes, PhD, associate director of environmental sciences at the New York City Public Health Laboratory, said the lab is receiving Zika-related specimens from about 50 patients every day. As of early September, the lab had performed testing for about 7,500 patients and received about 12,000 specimens. It began serological testing about two months ago.

In addition to human testing, the New York City lab is testing mosquitoes too, screening about 200 pools of trapped mosquitoes every week. Like other lab officials, Hughes said he is also concerned about the lab hitting capacity if another outbreak happens in the midst of Zika response.

“We really went from zero to 60 in a very short time,” Hughes said. An agency graphic shows that Zika testing requests for pregnant women went from zero in late March to nearly 2,500 in mid-July. “It’s the great unknown as to how much longer this will go on or whether this will become part of the everyday menu of tests we perform.”

Another Zika challenge both Hughes and Kubin mentioned was working with local obstetric/gynecology providers to receive specimens for testing, as such practices don’t typically work with public health labs. In New York City, the health department established a call center where providers can get more information; in Texas, public health officials partnered with professional pediatric and medical associations to disseminate information, among other measures. Out in California, Neil Silverman, MD, said educating medical providers is a “critical component” of Zika response.

A high-risk pregnancy specialist, Silverman is an obstetrician at the Center for Fetal Medicine & Women’s Ultrasound in Los Angeles and since February, has been serving as a perinatal consultant on Zika for the California Department of Public Health. In his consulting role, he helped craft messaging for obstetricians that not only educated on the nature and epidemiology of Zika, but on who should be tested and how to go about accessing testing. To paint a clearer picture of the process, Silverman pointed to his own experience.

Since the end of January, his practice has seen more than 200 pregnant women for Zika-related travel risks. At first, patient specimens were collected at the practice, then couriered to a nearby hospital lab, which then facilitated shipment to the county public health lab and on to CDC. Fortunately, the Los Angeles County public health lab now has Zika testing capability, but provider specimens are still couriered through a hospital lab. In particular, Silverman said, providers needed to know that any specimens sent to public health labs have to be accompanied with the proper epidemiologic paperwork; without it, testing can’t proceed.

“I get questions about Zika every single day,” he said about his practice. “The anxiety level is high and I think it’s only a matter of time before we start seeing some local cases.” As of September 16, California had no locally acquired Zika cases.

Silverman noted that as commercial labs have come online, it’s lessened the burden on California’s public health labs. But he also said that public health labs still offer one big advantage: they serve as a buffer against testing people who don’t need to be tested, making it easier for those truly at risk to access timely screening. Also, public health labs provide Zika testing for all those who need it, regardless of income or payer status, Silverman said, noting that one of the commercial labs his practice works with charges $165 upfront for Zika PCR testing.

“Our public health department and public health labs really are the boots on the ground,” he said. “They’re the sentinels when outbreaks occur, and it really is unfortunate that people don’t think of everything they do until there’s no money to fund them.”

Emergency funds still critically necessary  

Unfortunately, dealing with severe funding cuts and budget shortfalls while still maintaining core public health functions has become a mainstay of public health practice. However, in the face of a threat like Zika and its potential consequences for newborns and families, one would think emergency funding would be a slam-dunk.

Inside the public health lab Zika response | www.APHLblog.orgBut despite the concerted efforts of public health advocates, Congress has yet to authorize any emergency funding. In the face of such inaction, the White House redirected about $600 million away from Ebola response to fight Zika, and CDC was forced to redirect more than $44 million in Public Health Emergency Preparedness (PHEP) funds away from state and local health departments and toward national Zika response, though some of those funds returned to at-risk states and localities via CDC’s Epidemiology and Laboratory Capacity (ELC) program. The U.S. Department of Health and Human Services (HHS) redirected hundreds of millions of funds to domestic response as well, including $222 million that went to CDC.

But those are only stop-gap measures. In an August letter to key members of Congress, HHS Secretary Sylvia Burwell wrote that “CDC is on pace to virtually exhaust all of its domestic response funding by the end of the fiscal year.” Without additional funds, Burwell stated that CDC will have “severely limited” capacity to support mosquito control and surveillance and improve diagnostic Zika testing.

“Labs, like the rest of public health, are barely funded and because of that, they’re able to do a terrific job on a finite set of activities,” said Peter Kyriacopoulos, senior director of public policy at APHL. “For instance, they can do standard flu testing, but when there’s a pandemic flu outbreak they need additional resources because they’re working additional hours, using additional materials, using their machines more often, which leads to more maintenance…and all of that burden comes on top of their daily work. When you layer on top of that something like Ebola or Zika, that’s when the system begins to fray.”

In turn, federal emergency funding is still desperately needed, said Kyriacopoulos, who noted that APHL has had more meetings with congressional offices on Zika than it has on all other outbreaks combined. In particular, Kyriacopoulos worries that the inaction on Zika funding and resulting reprogramming of funds away from other public health priorities could set a dangerous precedent.

“Right now, we’re just kicking the can down the road,” he said. “This is not the way to effectively handle a public health crisis.”

Learn more about Zika: